52
The Dream of Elixir Vitae
CELL THERAPY
Gene therapy and RNAi are limited in the number of genes 
they can affect in cells. One way to overcome this limitation 
is by replacing the cells themselves, a process known as cell 
therapy. Since there are few theoretical restrictions as to the 
number of genetic modifications cells can endure, cell ther-
apy has a greater bandwidth. For example, in an experiment 
aimed  at  treating  the  immunodeficiency  disease  SCID-X1, 
cells from the immune system were extracted from a patient, 
genetically engineered, and inserted back again with encour-
aging results. [19]
One growing area involves stem cells. A stem cell is a sort 
of  unprogrammed  cell  that  has  the  potential  to  become 
any  type  of  cell  in  the  adult  body.  Aging  has  been  linked 
to an age-related inability of stem cells to replenish mature 
cells and so therapeutic interventions that enhance stem cell 
functional capacity might ameliorate the age-associated atro-
phies of several organ systems. [20] More importantly, with 
nuclear transfer experiments such as Dolly [3], it is now pos-
sible to turn back the clock and generate embryonic stem 
cells from an adult. [21;22] In theory, it is possible to geneti-
cally modify these cells according to needs, differentiate them 
into the necessary tissue or organ and then implant them to 
treat age-related diseases, a procedure called therapeutic clon-
ing. [23;24] Since these cells are genetically identical to the 
patients there are few or no problems of immune rejection.
The ability of stem cells to regenerate virtually all types of 
tissues holds great promise. [25] In theory, it is possible to 
create practically all components of a human being in the lab 
and then replace the patients organs and tissues one by one. 
Stem cells have been used with success against heart disease, 
[26] or to repair damage to the brain [27] and spinal cord. 
[28] Also, stem cells are incredibly versatile: transplantation of